Prognostic value of methylation status of RASSF1A gene as an independent factor of non-small cell lung cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 311-316, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-294815
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>Promoter hypermethylation of the RASSF1A gene is among the most abundant epigenetic deregulations in human cancer. The aim of this study is to investigate the relationship between the methylation status of RASSF1A promoter and the prognoses of non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>The methylation status of RASSF1A promoter in 150 NSCLC and 25 non-malignant tissues was determined using a methylation-specific polymerase chain reaction (MSP).</p><p><b>RESULTS</b>RASSF1A promoter hypermethylation was detected in 38.7% (58/150) of NSCLC tissues, but in none of the non-malignant tissues. The patients with hypermethylation of RASSF1A had a poor survival rate, and the relationship between the survival rate and hypermethylation of RASSF1A was statistically significant (P = 0.004). Then by using stepwise Cox proportional hazard regression testing, methylation status of RASSF1A was an independent factor affecting the NSCLC patients' survival (RR = 1.584, 95% CI 1.040-2.411, P = 0.032).</p><p><b>CONCLUSION</b>The hypermethylation of the RASSF1A promoter may be an independent prognostic factor of NSCLC after operation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Regiones Promotoras Genéticas
/
Carcinoma de Pulmón de Células no Pequeñas
/
Metilación de ADN
/
Proteínas Supresoras de Tumor
/
Genética
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Lung Cancer
Año:
2010
Tipo del documento:
Artículo
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