Combined effect of cosolvent and cyclodextrin on solubilization of insoluble drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 950-955, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-294907
ABSTRACT
<p><b>AIM</b>To investigate the combined effect of cosolvent and cyclodextrin (CD) on solubilization of insoluble drugs.</p><p><b>METHODS</b>Phase-solubility method was applied to determine solubilization of two diterpenoids in cosolvent / cyclodextrin combinations. The combined effect was evaluated and explained with an established mathematical model, and the model parameters were calculated by means of nonlinear regression analysis.</p><p><b>RESULTS</b>The strong agreement between the predicted and the observed solubility data supports the validity of the proposed model, with the determination coefficients of two regression models were 0.993 and 0.992, separately.</p><p><b>CONCLUSION</b>The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Solubilidad
/
Solventes
/
Algoritmos
/
Agua
/
Química
/
Beta-Ciclodextrinas
/
Diterpenos
/
2-Hidroxipropil-beta-Ciclodextrina
/
Modelos Químicos
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2006
Tipo del documento:
Artículo
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