A IL-6R antagonist 2520A produced by a fungal species / 药学学报
Acta Pharmaceutica Sinica
; (12): 662-665, 2006.
Article
en Zh
| WPRIM
| ID: wpr-294963
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.</p><p><b>METHODS</b>Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.</p><p><b>RESULTS</b>One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.</p><p><b>CONCLUSION</b>2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Péptidos Cíclicos
/
Farmacología
/
Bacillus subtilis
/
Compuestos Férricos
/
Estructura Molecular
/
Supervivencia Celular
/
Química
/
Receptores de Interleucina-6
/
Línea Celular Tumoral
/
Hongos Mitospóricos
Límite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2006
Tipo del documento:
Article