Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 841-844, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-295223
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.</p><p><b>METHODS</b>Ep-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 para-cancerous mucosa specimens.</p><p><b>RESULTS</b>Ep-CAM and cyclin D1 expressions were detected in 56.7% and 48.3% of the cancer tissues, respectively, significantly higher than those in the normal mucosa (P < 0.05). Ep-CAM expression was not correlated with clinicopathological data, however cyclin D1 expression was correlated with pathological differentiation and necrosis (P < 0.05). Survival analysis showed that patients with positive Ep-CAM or cyclin D1 expression had a shorter survival time than that in the patients without (P < 0.05). Moreover, Ep-CAM and cyclin D1 expressions were positively correlated with each other (r = 0.307, P = 0.017).</p><p><b>CONCLUSION</b>Ep-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Moléculas de Adhesión Celular
/
Diferenciación Celular
/
Tasa de Supervivencia
/
Carcinoma Adenoescamoso
/
Ciclina D1
/
Molécula de Adhesión Celular Epitelial
/
Neoplasias de la Vesícula Biliar
Tipo de estudio:
Estudio pronóstico
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2009
Tipo del documento:
Artículo
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