Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 687-690, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-295257
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of COX-2 and VEGF in clear cell renal cell carcinoma (CCRCC) and their correlation with tumor angiogenesis.</p><p><b>METHODS</b>Envision immunohistochemistry was used to determine the expression of COX-2 and VEGF, and microvessel density (MVD) was marked by CD34 in 80 CCRCC tissues and 20 normal kidney tissues. The relationship between the above mentioned markers were analyzed.</p><p><b>RESULTS</b>Expressions of COX-2 and VEGF were noted in both CCRCC and normal kidney tissues. The positive rates of COX-2 and VEGF were significantly higher in CCRCC than in normal kidney (P < 0.05); The expression of COX-2 was correlated with TNM stage (P < 0.05), histological grade (P < 0.05) and lymph node metastasis (P < 0.05) in CCRCC, but not with age (P = 0.663) and diameter of tumor (P = 0.528). Both COX-2 expression (r = 0.851, P < 0.01) and VEGF expression (r = 0.736, P < 0.01) were significantly associated with MVD in CCRCC. There was a positive correlation between expression of cox-2 and that of VEGF in CCRCC.</p><p><b>CONCLUSION</b>COX-2 expression is correlated with tumor angiogenesis in CCRCC. It is likely that VEGF is one of the most important mediators in the COX-2 angiogenic pathway.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Carcinoma de Células Renales
/
Factor A de Crecimiento Endotelial Vascular
/
Ciclooxigenasa 2
/
Microvasos
/
Neoplasias Renales
/
Metástasis Linfática
/
Metabolismo
/
Estadificación de Neoplasias
/
Neovascularización Patológica
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2009
Tipo del documento:
Artículo
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