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Detection of leukemia-derived microparticles in the monitoring of chronic myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 138-141, 2014.
Artículo en Chino | WPRIM | ID: wpr-295692
ABSTRACT
<p><b>OBJECTIVE</b>To exam the role of leukemia cells-derived microparticles in the post-complete molecular response stratification.</p><p><b>METHODS</b>Blood samples from 29 patients diagnosed with chronic myeloid leukemia (CML) were collected. Microparticles (MP) were extracted from the peripheral blood. Real-time PCR was performed to measure the level of BCR-ABL mRNA.</p><p><b>RESULTS</b>BCR-ABL mRNA could be stably detected both in MP and peripheral blood cells; BCR-ABL in MP showed significant difference within complete molecular response, major molecular response and complete cytogenetic response (9.1±2.8, 25.2±6.9 and 62.8±6.3 respectively, P<0.05). BCR-ABL was detected in MP even when it was negative in peripheral blood cells (3.7-15.3). For patients with complete molecular response, BCR-ABL in MP but not cells were significantly different between imatinib and stem cell transplant recipients (3.3±2.1 vs 9.1±2.8, P<0.05).</p><p><b>CONCLUSION</b>This study indicated that MP may serves as a new target for monitoring of CML. Quantification of BCR-ABL in MP may offer a novel strategy for stratification of molecular response.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ARN Mensajero / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Micropartículas Derivadas de Células / Reacción en Cadena en Tiempo Real de la Polimerasa / Genética Tipo de estudio: Estudio diagnóstico Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / ARN Mensajero / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Micropartículas Derivadas de Células / Reacción en Cadena en Tiempo Real de la Polimerasa / Genética Tipo de estudio: Estudio diagnóstico Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2014 Tipo del documento: Artículo