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The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype / 中华预防医学杂志
Chinese Journal of Preventive Medicine ; (12): 180-183, 2002.
Artículo en Inglés | WPRIM | ID: wpr-295776
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.</p><p><b>METHODS</b>Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.</p><p><b>RESULTS</b>The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).</p><p><b>CONCLUSION</b>In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Antígenos HLA-DQ / Antígenos HLA-DR / Desequilibrio de Ligamiento / China / Clasificación / Vacunas contra Hepatitis B / Pueblo Asiatico / Alergia e Inmunología / Cadenas beta de HLA-DQ Tipo de estudio: Estudio de etiología Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Journal of Preventive Medicine Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Antígenos HLA-DQ / Antígenos HLA-DR / Desequilibrio de Ligamiento / China / Clasificación / Vacunas contra Hepatitis B / Pueblo Asiatico / Alergia e Inmunología / Cadenas beta de HLA-DQ Tipo de estudio: Estudio de etiología Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Journal of Preventive Medicine Año: 2002 Tipo del documento: Artículo