MLL1/WDR5 complex in leukemogenesis and epigenetic regulation / 癌症
Chinese Journal of Cancer
;
(12): 240-246, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-296290
ABSTRACT
MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Histonas
/
Leucemia
/
Activación Transcripcional
/
N-Metiltransferasa de Histona-Lisina
/
Metilación de ADN
/
Epigénesis Genética
/
Complejos Multiproteicos
/
Proteína de la Leucemia Mieloide-Linfoide
/
Genética
/
Lisina
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Cancer
Año:
2011
Tipo del documento:
Artículo
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