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Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 224-228, 2017.
Artículo en Inglés | WPRIM | ID: wpr-296493
ABSTRACT
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent and prevalent nitrosamine procarcinogen found in cigarette smoke. The aim of this work is to study alterations in peroxiredoxin (Prx) expression induced by NNK during carcinogenesis. Characterization of Prx genes from hamster was performed using bioinformatics. V79 cells were induced with different concentrations of NNK (0.1-0.4 mg/mL), and the expression levels of six Prx genes (Prx1-Prx6) were measured by qRT-PCR 24 h following NNK treatment. Prx gene expression was induced by NNK stress, and the highest transcription levels were induced by over 20.42-fold relative to that of the control. NNK induced alterations in Prx expression over the course of lung cancer, which means Prxs may play important roles in ROS detoxification under NNK stress and their functions are complementary.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinógenos / Línea Celular / Supervivencia Celular / Regulación de la Expresión Génica / Cricetulus / Relación Dosis-Respuesta a Droga / Toxicidad / Peroxirredoxinas / Genética / Metabolismo Límite: Animales Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinógenos / Línea Celular / Supervivencia Celular / Regulación de la Expresión Génica / Cricetulus / Relación Dosis-Respuesta a Droga / Toxicidad / Peroxirredoxinas / Genética / Metabolismo Límite: Animales Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2017 Tipo del documento: Artículo