Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 215-219, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-296495
ABSTRACT
Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer's disease (AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life. This study was aimed to investigate the effects of lead exposure of pregnant mice on the expressions of insulin-degrading enzyme (IDE) and nerve growth factor (NGF) in the hippocampus of their offspring. Blood samples were collected from the tail vein, and after anesthetizing the pups, the brain was excised on postnatal day 21. Lead concentrations were determined by graphite furnace atomic absorption spectrophotometry, and the expressions of IDE and NGF were determined by immunohistochemistry and Western blotting. Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Regulación hacia Abajo
/
Regulación Enzimológica de la Expresión Génica
/
Regulación del Desarrollo de la Expresión Génica
/
Toxicidad
/
Genética
/
Hipocampo
/
Insulisina
/
Plomo
/
Metabolismo
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2017
Tipo del documento:
Artículo
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