Advances in targeted therapy for childhood acute myeloid leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 832-836, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-297199
ABSTRACT
At present, acute myeloid leukemia (AML) accounts for about 15%-20% of childhood acute leukemia. Although overall survival rate is increasing with the help of risk stratification, stratification of chemotherapy, and supportive treatment, conventional pharmacotherapy still has a limited clinical effect and certain limitations in improving remission rate in previously untreated patients and reducing recurrence after remission. With the development of precision medicine, the mechanisms of targeted therapy, including abnormal activation of AML-related signaling pathways and epigenetic modification, have been found in recent years. Molecular-targeted drugs can therefore act on specific receptors and target genes to improve clinical effect and the prognosis of AML patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Leucemia Mieloide Aguda
/
Mortalidad
/
Epigénesis Genética
/
Quimioterapia
/
Terapia Molecular Dirigida
/
Inmunoterapia
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2017
Tipo del documento:
Artículo
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