Clinical efficacy and safety of recombinant human-growth hormone in the treatment of idiopathic asthenospermia / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the clinical efficacy and safety of recombinant human-growth hormone (rhGH) in the treatment of idiopathic asthenospermia.</p><p><b>METHODS</b>Forty patients with idiopathic asthenospermia were recruited, randomly divided into an rhGH group and a control group and treated for 3 months. In addition to routine treatment, the rhGH group (n = 18) received rhGH, while the control group (n = 18) underwent the routine treatment only. Before and after the treatment, semen samples were obtained, analyzed and graded according to the WHO laboratory manual, and the serum sexual hormone, thyroxin, liver and kidney function, blood cholesterol and blood glucose level were detected.</p><p><b>RESULTS</b>Sperm vitality was statistically increased, (28.60 +/- 32.89) % in the rhGH group and (8.42 +/- 25.87) % in the control (P < 0.01), and so was sperm (a + b) motility, (18.56 +/- 21.19) % in the rhGH group and (8.12 +/- 24.34) % in the control (P < 0.05).</p><p><b>CONCLUSION</b>rhGH can be used safely as an effective supplement to medicinal treatment of idiopathic asthenospermia.</p>