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Effect of simian vacuolating virus 40 on development and differentiation of dendritic cells from Rhesus macaque / 病毒学报
Chinese Journal of Virology ; (6): 344-348, 2009.
Artículo en Chino | WPRIM | ID: wpr-297950
ABSTRACT
To study the effect of simian vacuolating virus 40 (SV40) on development and differentiation of dendritic cells (DC) from rhesus macaque, the peripheral blood-derived dendritic cells from rhesus monkey were pulsed with inactivated SV40 and infective SV40, respectively at the 5th day post DC cultivation. Expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface at the 7th, 9th day post DC cultivation were analyzed by flow cytometry (FCM). The results showed that expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface in the inactivated SV40-pulsed experimental group were higher than those in the infective SV40-pulsed experimental group (P < 0.05). These cell surface molecules represented characteristic development and differentiation phase of DC. Down-regulation of expressions of these cell surface molecules indicated that infective SV40 might hamper differentiation and maturation of dendritic cells from rhesus monkey.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Virología / Células Dendríticas / Inmunoglobulinas / Glicoproteínas de Membrana / Antígenos HLA-DR / Antígenos CD / Diferenciación Celular / Células Cultivadas / Virus 40 de los Simios Límite: Animales Idioma: Chino Revista: Chinese Journal of Virology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Virología / Células Dendríticas / Inmunoglobulinas / Glicoproteínas de Membrana / Antígenos HLA-DR / Antígenos CD / Diferenciación Celular / Células Cultivadas / Virus 40 de los Simios Límite: Animales Idioma: Chino Revista: Chinese Journal of Virology Año: 2009 Tipo del documento: Artículo