Lead compound optimization strategy (2)--structure optimization strategy for reducing toxicity risks in drug design / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1-15, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-297978
ABSTRACT
Idiosyncratic adverse drug reactions (IDR) induce severe medical complications or even death in patients. Alert structure in drugs can be metabolized as reactive metabolite (RM) in the bodies, which is one of the major factors to induce IDR. Structure modification and avoidance of alert structure in the drug candidates is an efficient method for reducing toxicity risks in drug design. This review briefly summarized the recent development of the methodologies for structure optimization strategy to reduce the toxicity risks of drug candidates. These methods include blocking metabolic site, altering metabolic pathway, reducing activity, bioisosterism, and prodrug.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Relación Estructura-Actividad
/
Sitios de Unión
/
Diseño de Fármacos
/
Sistema Enzimático del Citocromo P-450
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
/
Recall de Medicamento
/
Descubrimiento de Drogas
/
Metabolismo
/
Métodos
Tipo de estudio:
Estudio de etiología
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
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