Research progress of the small molecule covalent inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 158-165, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-297998
ABSTRACT
Small molecule covalent inhibitors, or called as irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity. Nevertheless, these agents may also exhibit larger toxicity once off-target effects arise. This "double-edged swords" property often leads drug researchers to avoid attaching them. In recent years, some problems such as drug resistance are difficult to be solved with reversible inhibitors leading researchers to pay more attention on the covalent inhibitors. In this review, we shall make a short summary to the recent research progress of covalent inhibitors and the interaction modes between covalent inhibitors and their target protein residues.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Unión Proteica
/
Resistencia a Medicamentos
/
Estructura Molecular
/
Inhibidores de Serina Proteinasa
/
Química
/
Hepatitis C
/
Usos Terapéuticos
/
Inhibidores de Proteínas Quinasas
/
Quimioterapia
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
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