Fluorescence in-situ hybridization as a diagnostic tool for cutaneous melanoma / 中华病理学杂志
Chinese Journal of Pathology
; (12): 37-41, 2015.
Article
en Zh
| WPRIM
| ID: wpr-298160
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the utility of fluorescence in situ hybridization as a diagnostic tool for cutaneous melanoma.</p><p><b>METHODS</b>Twenty cutaneous melanomas and 20 cutaneous nevi from pathology files were selected and analyzed by Vysis melanoma FISH probe kit targeting 3 loci on chromosome 6 (MYB, CEP6 and RREB1) and 1 locus on 11q (CCND1) and data were interpreted based on the Abbott criteria provided by the kit.</p><p><b>RESULTS</b>Informative FISH results were obtained in 16 melanomas and 18 nevi. Chromosomal aberrations were detected in 12 of the 16 melanomas and only 1 of 18 nevi.</p><p><b>CONCLUSION</b>FISH is a useful diagnostic tool and able to distinguish cutaneous nevus from melanoma with good sensitivity and specificity.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neoplasias Cutáneas
/
Aberraciones Cromosómicas
/
Sensibilidad y Especificidad
/
Hibridación Fluorescente in Situ
/
Ciclina D1
/
Diagnóstico
/
Diagnóstico Diferencial
/
Genética
/
Melanoma
/
Nevo
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Año:
2015
Tipo del documento:
Article