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Copy number variations in pediatric ETV6/RUNX1 positive acute lymphoblastic leukemia / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 209-213, 2016.
Artículo en Chino | WPRIM | ID: wpr-298275
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the copy number variations (CNVs) in pediatric ETV6/RUNX1 gene positive acute lymphoblastic leukemia(ALL) and its correlation with clinical features and prognosis.</p><p><b>METHOD</b>Totally 141 children (<14 years of age) with newly diagnosed ETV6/RUNX1 positive ALL in Institute of Hematology and Blood Diseases Hospital, were included from January 2006 to November 2012. The CNVs were analyzed by multiplex ligation-dependent probe amplification (MLPA). The survival rate between the patients with CNVs were explored. Overall survival (OS) and event-free survival (EFS) were estimated by the Kaplan-Meier method and compared with the log-rank test.</p><p><b>RESULT</b>Among the 141 cases, 55.3% (n=78) were boys and 44.7% (n=63) were girls and the median age was 4 (1-13) years. The estimated 5-year DFS rate for the patients was (84±4)%. The estimated 5-year OS rate for the patients was (85±4)%. Ninety-five patients were tested MLPA. CNVs were detected in 73 cases (76.8%). CNVs of genes EBF1(15.8%), CDKN2A/2B(18.9%), PAX5(21.1%), ETV6(54.8%), BTG1(10.5%) were detected in more than 10% of the patients. Among the 95 patients, EBF1 deletions were found in 9 patients and EBF1 amplifications were found in 6 patients; 5-year recurrence-free survival (RFS) was statistically significant among 3 groups (χ(2)=9.809, P=0.007) . PAX5 deletions were found in 13 patients and PAX5 amplifications were found in 7 patients; the difference in 5-year RFS was statistically significant between 3 groups(χ(2)=7.622, P=0.022). ETV6 deletions were found in 39 patients and ETV6 amplifications were found in 13 patients; the difference in 5-year RFS was statistically significant among the 3 groups (χ(2)=11.045, P=0.004).</p><p><b>CONCLUSION</b>The CNVs had prognostic relevance in ETV6/RUNX1 positive ALL.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Proteínas Represoras / Tasa de Supervivencia / Supervivencia sin Enfermedad / Proteínas Proto-Oncogénicas c-ets / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Leucemia-Linfoma Linfoblástico de Células Precursoras / Variaciones en el Número de Copia de ADN / Reacción en Cadena de la Polimerasa Multiplex Tipo de estudio: Estudio pronóstico Límite: Adolescente / Niño / Humanos Idioma: Chino Revista: Chinese Journal of Pediatrics Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Proteínas Represoras / Tasa de Supervivencia / Supervivencia sin Enfermedad / Proteínas Proto-Oncogénicas c-ets / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Leucemia-Linfoma Linfoblástico de Células Precursoras / Variaciones en el Número de Copia de ADN / Reacción en Cadena de la Polimerasa Multiplex Tipo de estudio: Estudio pronóstico Límite: Adolescente / Niño / Humanos Idioma: Chino Revista: Chinese Journal of Pediatrics Año: 2016 Tipo del documento: Artículo