Study on preparation of berberine microemulsion and its absorption in intestine / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 398-401, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-298393
ABSTRACT
<p><b>OBJECTIVE</b>To prepare berberine microemulsion, and to investigate its properities and the absorption character in rat intestine in situ.</p><p><b>METHOD</b>The optimum formulation of the blank microemulsion selected by pseudo tertiary phase diagrams and the berberine microemulsion was prepared based on the blank microemulsion. The viscosity, conductance, refraction rate and particle size of berberine microemulsion were surveyed. An in situ rat perfusion method was used to investigate the intestinal absorption of berberine microemulsion. A UV method for determination of berberine in the intestinal flux was established.</p><p><b>RESULT</b>The viscosity, conductance, refraction rate and particle size of berberine microemulsion were 2.11 cPas, 125.5 microomega, 1.363 and 24.0 nm, respectively. The absorption rate of berberine at the ileum was the best. The absorption of berberine microemulsion at the ileum was significantly higher than that of raw medicine (P < 0.01).</p><p><b>CONCLUSION</b>The microemulsion system might improve the absorption of berberine in the intestinal tract.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Fisiología
/
Piel
/
Absorción Cutánea
/
Solubilidad
/
Berberina
/
Administración Cutánea
/
Farmacocinética
/
Tecnología Farmacéutica
/
Sistemas de Liberación de Medicamentos
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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