Protective effects of AST and ASI on memory impairment and its mechanism in senescent rats treated by GC / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 199-203, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-298432
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effects and mechanisms of astragaloside (AST) and astragalus saponin I (ASI) on the memory impairment in senescent rats treated by glucocorticoid (GC).</p><p><b>METHOD</b>Y maze test was performed to determine the effects of AST and ASI on memory impairment of hydrocortisone(HC)-induced senescent rats. Using Ca2+ sensitive fluorescent indicator (Furo-2), free intracellular calcium concentration ([Ca2+]i) was measured by double wavelength fluorescence sepectrophotometer in thymocytes and hippocampal neurons induced dexamethasone (DEX). And apoptosis was detected by DNA gel electrophoresis and flow cytometry.</p><p><b>RESULT</b>Compared with HC control, AST and ASI can improve the memory of the senescent rats treated by HC, lower [Ca2+]i and suppress apoptosis of thymocytes and hippocampal neurons induced by DEX.</p><p><b>CONCLUSION</b>AST and ASI can delay the aging in rats treated by HC, and its mechanism may includ lowering[Ca2+]i and suppressing the apoptosis of thymocytes and hippocampal neurons.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Saponinas
/
Peso Corporal
/
Envejecimiento
/
Dexametasona
/
Calcio
/
Apoptosis
/
Espacio Intracelular
/
Glucocorticoides
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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