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Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 697-700, 2007.
Artículo en Chino | WPRIM | ID: wpr-298515
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of GLUT1, p63 and DNA-Pkcs in serous ovarian tumors and their significance.</p><p><b>METHODS</b>GTUL1, p63 and DNA-Pkcs expression at protein level was detected by immunohistochemistry in patients with serous ovarian tumors. Chi-square analysis was used to assess if their expression is associated with clinicopathologic characteristics of the tumors.</p><p><b>RESULTS</b>Cells in the normal ovarian tissues were not stained with GTUL1 and p63 antiserum, but DNA-Pkcs was positively stained. The intensity of GTUT1 and p63 expression was stronger in malignant ovarian serous tumors compared with other subtypes (P < 0.01). There were significant differences of DNA-PKcs among normal ovaries (100.0%), benign (95.0%), borderline (90.0%) and malignant (60.0%) serious ovarian neoplasms (P < 0.01). The level of GLUT-1 expression was correlated with FIGO staging, intraperitoneal implantation, ascites and lymph node metastasis (P < 0.05). p63 expression was associated with clinicopathologic characteristics except ascites (P < 0.05). DNA-PKcs was only correlated with FIGO staging and lymph node metastasis (P < 0.05).</p><p><b>CONCLUSION</b>The results suggest that the abnormal expression of GTUT1, p63 and DNA-Pkcs may perhaps participate in serous ovarian tumor occurrence and development and may be considered as a marker reflecting tumor malignant behavior.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Ováricas / Ovario / Patología / Factores de Transcripción / Inmunohistoquímica / Proteínas Nucleares / Regulación Neoplásica de la Expresión Génica / Transactivadores / Cistadenoma Seroso / Cistadenocarcinoma Seroso Límite: Adolescente / Adulto / Anciano / Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Ováricas / Ovario / Patología / Factores de Transcripción / Inmunohistoquímica / Proteínas Nucleares / Regulación Neoplásica de la Expresión Génica / Transactivadores / Cistadenoma Seroso / Cistadenocarcinoma Seroso Límite: Adolescente / Adulto / Anciano / Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2007 Tipo del documento: Artículo