Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 738-741, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-298698
ABSTRACT
<p><b>OBJECTIVE</b>To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.</p><p><b>METHODS</b>The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.</p><p><b>RESULT</b>The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.</p><p><b>CONCLUSION</b>Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Orina
/
Biomarcadores
/
Análisis de los Mínimos Cuadrados
/
Diagnóstico
/
Metaboloma
/
Neoplasias Pulmonares
/
Modelos Biológicos
/
Nucleósidos
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Adulto
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS