Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock.</p><p><b>METHOD</b>We measured the serum level of Apelin with ELISA on different observation days (the 1st, 3rd, and 10th day obtaining the diagnosis) in 26 patients with severe sepsis and septic shock.</p><p><b>RESULTS</b>Serum Apelin significantly increased in sepsis patients when compared with the normal control group (P<0.01); The serum Apelin levels significantly changed among different observation days (P< 0.01). Serum Apelin level was significantly higher in patients with septic shock than those with severe sepsis (P<0.01).</p><p><b>CONCLUSION</b>Serum Apelin level changes in patients with severe sepsis and septic shock, which may provide clues in diagnosis and prognosis.</p>