Current advances in the mechanic studies of human papillomavirus-induced oncogenesis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 673-677, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-298760
ABSTRACT
Human papillomavirus (HPV) is a common small DNA tumor virus that specifically infects squamous epithelial cells and causes benign or malignant epithelial lesions such as genital warts and cervical cancer. High-risk HPV is detected in specimens of more than 90% of cervical cancer. In the 7. 9 kb genome of HPV, E6 and E7 are the crucial viral oncoproteins that consistently maintained after viral integration into host cell genome. These two proteins interfere with cell proliferation and differentiation through interacting with important tumor suppressors including p53 and pRb. High-risk HPV E6/E7 also induces genomic instability, facilitating cell transformation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Papillomaviridae
/
Patología
/
Fisiología
/
Virología
/
Diferenciación Celular
/
Transformación Celular Neoplásica
/
Neoplasias del Cuello Uterino
/
Proteínas Oncogénicas Virales
/
Infecciones por Papillomavirus
/
Inestabilidad Genómica
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2007
Tipo del documento:
Artículo
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