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Interaction of E3 ligase HUWE1 and eukaryotic translation initiation factor eIF4E / 药学学报
Acta Pharmaceutica Sinica ; (12): 1543-1546, 2014.
Artículo en Chino | WPRIM | ID: wpr-299100
ABSTRACT
To explore the regulation of eIF4E, we screened the protein interacting with eIF4E from human cDNA library by using yeast two-hybrid system. Several clones interacting with eIF4E were identified. One of them was homologous with HUWE1 (HECT, UBA and WWE domain containing 1, also named as ARF-BP1, HECTH9 or HUWE1). Cell co-immunoprecipitation showed that eIF4E could bind to HUWE1 in mammalian cells. We also found that HUWE1 bearing the HECT domain is necessary for its association with eIF4E.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factor 4E Eucariótico de Iniciación / Ubiquitina-Proteína Ligasas / Metabolismo Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factor 4E Eucariótico de Iniciación / Ubiquitina-Proteína Ligasas / Metabolismo Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo