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Synthesis and antifatigue activities of new benzamide derivatives / 药学学报
Acta Pharmaceutica Sinica ; (12): 1442-1445, 2014.
Artículo en Chino | WPRIM | ID: wpr-299114
ABSTRACT
To explore novel antifatigue agents targeting with AMPA receptor, 10 compounds were synthesized and their structures were confirmed by 1H NMR, ESI-MS and elemental analysis. 1-BCP was treated as the leading compound. The antifatigue activities were evaluated by weight-loaded forced swimming test, and the AMPA receptor binding affinities were tested with radioligand receptor binding assays. The results unveiled that 5b appeared to possess potent antifatigue activities and high affinity with AMPA receptor, which deserved further studies.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Piperidinas / Ensayo de Unión Radioligante / Natación / Benzamidas / Química / Receptores AMPA / Dioxoles / Fatiga / Metabolismo Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Piperidinas / Ensayo de Unión Radioligante / Natación / Benzamidas / Química / Receptores AMPA / Dioxoles / Fatiga / Metabolismo Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo