Ellagic acid-induced hypercoagulable state in animals: a potentially useful animal hypercoagulable model for evaluation of anticoagulants / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 237-242, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-299424
ABSTRACT
<p><b>OBJECTIVE</b>To establish and evaluate a hypercoagulable animal model for the assessment of anticoagulants.</p><p><b>METHODS</b>Forty mice, thirty-two rats, and twenty-four rabbits were randomly and equally divided into control group (saline) and three ellagic acid (EA)-treated groups (low, middle, and high doses). In the mice, bleeding time (BT) was estimated with tail transaction, and clotting time (CT) with template method. Prothrombin time (PT) and the activated partial thromboplastin time (APTT) in rats and rabbits were measured by means of Quick's one-stage assay and modified APTT assay respectively. In addition, thrombin activity was estimated in rats with PT assay using a hemagglutination analyzer. The circulating platelet aggregates were detected in rabbits through platelet counting and presented as the circulating platelet aggregate ratio (CPAR).</p><p><b>RESULTS</b>EA shortened BT and CT in mice, PT and APTT in rats, and increased thrombin activity and CPAR, all in a dose-dependent manner. EA also brought reduction of PT and APTT in rabbits in dose- and time-dependent manners.</p><p><b>CONCLUSION</b>EA could induce hypercoagulable state through activating coagulation system and platelets in mice, rats, and rabbits.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tiempo de Protrombina
/
Trastornos de la Coagulación Sanguínea
/
Agregación Plaquetaria
/
Ratas Sprague-Dawley
/
Modelos Animales
/
Usos Terapéuticos
/
Evaluación Preclínica de Medicamentos
/
Quimioterapia
/
Ácido Elágico
/
Ratones Endogámicos ICR
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Sciences Journal
Año:
2010
Tipo del documento:
Artículo
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