Hypertensive effect of sublingual captopril

ABSTRACT

32 patients (male 21) with average ages of 62 (11,4, hypertension (systolic blood pressure 180mmHg, diastolic blood pressure 110 mmHg) received the sublingual captopril at dose of 25 mg. The hemodynamometery was implemented before and after 5, 15, 30 and 60 minutes of using the drug. If the blood pressure was not reduced to wanted level, the patient indicated more one tablet. If the blood pressure did not reduce about 25%, patients will be treated by combination of captopril with other drugs. The results have shown that efficacy at dose of 25 mg, 15 cases, at dose of 50 mg 12 cases; ineffect and poor effect 5 cases. Initial time of effect 7 (1.04 minutes after using; time for maximum effect 61 (24.3 minutes after using. The study concluded that captopril can be used in the urgent hypertension