Application of CADD on multi-target drug R&D in natural products / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1951-1955, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-299852
ABSTRACT
Multi-target drugs can simultaneously adjust multiple links of the disease network. Despite the higher efficacy and lower toxicity caused by single targets, multi-target drugs become ideal drugs for treating complicated diseases as well the main direction of drug R & D. By virtue of their structural diversity, higher multi-target activity and lower toxicity, natural products become an important source for developing multi-target drugs. Computer-aided drug design (CADD) is a commonly used multi-target drug R&D method, which mainly includes virtual screening and pharmacophore design. In this paper, the authors made a systematical analysis and discussed the prospects and advantages of various methods for multi-target drug R&D with natural products.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Productos Biológicos
/
Diseño de Fármacos
/
Diseño Asistido por Computadora
/
Investigación Biomédica
/
Terapia Molecular Dirigida
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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