Expression and significance of cyclin D1 in human adenoid cystic carcinoma / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters.</p><p><b>METHODS</b>The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.</p><p><b>RESULTS</b>The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P < 0.05). The expression level of PA was significantly lower than ACC (P < 0.05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P < 0.05), but not with sex, age, tumor site, recurrence, metastasis.</p><p><b>CONCLUSION</b>High expression of cyclin D1 promotes the formation and development of ACC.</p>