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Progress in clinical studies of chimeric antigen receptor engineered T cells for treatment of childhood cancer / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1219-1224, 2017.
Artículo en Chino | WPRIM | ID: wpr-300418
ABSTRACT
Nowadays, the 5-year survival rate of childhood cancer patients can be more than 80%, but some patients with relapse and refractory cancers have shown no good response to traditional strategies. Chimeric antigen receptor engineered T (CAR-T) cell therapy is promising for these patients. CAR-T cells recognize the tumor-associated antigens in a non-major histocompatibility complex-restricted manner, so their anti-tumor ability is enhanced. There are four generations of CAR-T cells now. The complete remission rate of pediatric patients with relapse and refractory acute lymphoblastic leukemia can be as high as 90% when treated with CD19-targeting CAR-T cells. Furthermore, CAR-T cell therapy can also be used to bridge to transplantation and donor CAR-T cell infusion can be a strategy to prevent relapse after hematopoietic stem cell transplantation. As to solid tumors, only patients with neuroblastoma present good response to the GD2-targeting CAR-T cell therapy. The toxic or side effects of CAR-T cell therapy include cytokine release syndrome, off-tumor effect, tumor lysis syndrome, and insertion mutation. Although the CD19-targeting CAR-T cell therapy for childhood cancer can result in a high remission rate, the relapse rate is high, including CD19and CD19relapse. The mechanisms for relapse merit further investigatio.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / Trasplante / Receptores de Antígenos de Linfocitos T / Linfocitos T / Inmunoterapia Adoptiva / Antígenos CD19 / Alergia e Inmunología / Genética / Métodos / Neoplasias Límite: Niño / Humanos Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / Trasplante / Receptores de Antígenos de Linfocitos T / Linfocitos T / Inmunoterapia Adoptiva / Antígenos CD19 / Alergia e Inmunología / Genética / Métodos / Neoplasias Límite: Niño / Humanos Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2017 Tipo del documento: Artículo