Evaluation of tissue strain and strain rate imaging for left heart function in children with systemic lupus erythematosus / 中华儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the diagnostic value of the tissue strain imaging in myocardial dysfunction in children with systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>24 patients with SLE and 32 healthy controls underwent conventional and tissue Doppler echocardiography. Peak strain and strain rate value during systolic and diastolic phases as well as E/A, LVFS, LVEF were measured in both SLE and the control group subjects.</p><p><b>RESULTS</b>The E/A, LVFS and LVEF did not significantly differ between SLE children and controls (P > 0.05). The systolic peak strains and strain rates of SLE children were lower than those of the controls but there was no significant difference (P > 0.05). The diastolic peak strains and strain rates of SLE children were significantly lower than those of the controls (P < 0.01). The diastolic peak strains and strain rates of anticardiolipin antibodies (aCL) positive children were significantly lower than the aCL negative ones (P < 0.05).</p><p><b>CONCLUSION</b>Strain and strain rate combined with aCL could sensitively detect myocardial dysfunction of children with SLE.</p>