Therapeutic efficiency of amphotericin B liposome modified by RMP-7 to transport drug across blood brain barrier / 药学学报

ABSTRACT

<p><b>AIM</b>To study the therapeutic efficiency of amphotericin B liposome (AmB-L) targeting to the brain in mice with meningitis.</p><p><b>METHODS</b>Amphotericin B liposome targeting to the brain were prepared by film-sonication method. Their concentration and encapsulation percentage were determined. The Candida albicans was injected into the brain of BALB/c mice and the meningitis model was set up. Then the therapeutic efficiency of amphotericin B liposome targeting to the brain was studied.</p><p><b>RESULTS</b>The encapsulation percentage of amphotericin B liposome was 93.3%. The meningitis model was set up after the Candida albicans was injected into the brain of BALB/c mice for 2 h. The therapeutic efficiency was increased after conjugating RMP-7 (the commercial nama is Cereport) to the surface of amphotericin B liposome.</p><p><b>CONCLUSION</b>The therapeutic efficiency of Amphotericin B liposome targeting to the brain in the mice with meningitis was better than that of the common amphotericin B liposome and the life of the mice in AmB-L-PEG-RMP-7 group was longer than that of the mice in AmB-L-PEG group and AmB-L-PEG + RMP-7 group.</p>