Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population / 药学学报
Acta Pharmaceutica Sinica
; (12): 161-163, 2004.
Article
en Zh
| WPRIM
| ID: wpr-301124
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population.</p><p><b>METHODS</b>The genetic polymorphism of 140 healthy Chinese were analysed by PCR-RFLP (restriction fragment length polymorphism).</p><p><b>RESULTS</b>Of 52 genotyped male subjects, 23 (44.23%) were homozygous for wildtype (wt/wt), 6 (11.54%) were homozygous for CYP2C19 m1 (m1/m1), and 23 (44.23%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); and among the 88 genotyped female subjects, 31 (35.23%) were homozygous for wildtype (wt/wt), 13 (14.82%) were homozygous for CYP2C19 m1 (m1/m1), and 44 (50.0%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); no homozygous genotype for CYP2C19 m2 (m2/m2) was found in the study.</p><p><b>CONCLUSION</b>There is no statistical difference in ocurance of wt/wt and m1/m1 between in male and in female, so gender have no significant effect on genetic polymorphism of cytochrome CYP2C19.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
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Hidrocarburo de Aril Hidroxilasas
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China
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Factores Sexuales
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Reacción en Cadena de la Polimerasa
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Pueblo Asiatico
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Citocromo P-450 CYP2C19
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Frecuencia de los Genes
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Genética
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Genotipo
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2004
Tipo del documento:
Article