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Change of plasma TH1/TH2 cytokines levels in patients with hemorrhagic fever with renal syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 108-112, 2010.
Artículo en Chino | WPRIM | ID: wpr-301584
ABSTRACT
<p><b>OBJECTIVE</b>To observe changes in T cell subsets and TH1/TH2 secreted cytokines in the plasma of patients with hemorrhagic fever with renal syndrome (HFRS).</p><p><b>METHODS</b>Totally 22 patients with HFRS (9 mild cases and 13 moderate cases) were enrolled. Blood samples were taken 1, 4, and 12 weeks after presentation. T cell subsets were tested by flow cytometry (FCM), and the expression of cytokines in plasma were analysed with enzyme-linked immunosorbent assay (ELISA). Another 16 healthy blood donors were enrolled as the control group.</p><p><b>RESULTS</b>CD3 + CD8 + T lymphocytes increased at week 1 and 4 (P < 0.01), which was more significant in mild cases than in moderate cases (P < 0.05). The change of CD3 + CD4 + T lymphocytes during the disease course were not significantly different from that in control group (P > 0.05). One week after presentation, TH1 [interleukin (IL)-2 and interferon-gamma (IFN-gamma)] and TH2 (IL-6, IL-10) cytokine productions were significantly higher in HFRS patients than in the control group (P < 0.01); IL-2 and IL-10 remained high levels during the whole observation period, and were still significantly higher than in the control group (P < 0.01). At week 4, the plasma IL-5 level was significantly higher in HFRS patients than in the control group (P < 0.01), and were still significantly higher than in the control group at week 12 (P < 0.01). At week 1 and 4, the plasma INF-gamma levels were significantly higher in moderate patients than in mild patients (P < 0.05); at week 12, the plasma IL-10 level was significantly higher in moderate patients than in mild patients(P < 0.05).</p><p><b>CONCLUSIONS</b>CD3 + CD4 + T lymphocytes remarkably increases at the early stage of disease in patients with mild HFRS. The early cell mediated immune response is helpful for disease control. The cytokines INF-gamma and IL-10 increase more obviously in moderate patients, indicating that cytokines also are key pathogenic factors of HRFS.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Subgrupos de Linfocitos T / Interleucinas / Interferón gamma / Alergia e Inmunología / Fiebre Hemorrágica con Síndrome Renal Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Subgrupos de Linfocitos T / Interleucinas / Interferón gamma / Alergia e Inmunología / Fiebre Hemorrágica con Síndrome Renal Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2010 Tipo del documento: Artículo