Current situation researching of methylation in tumor / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 786-790, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-301607
ABSTRACT
The disorders of DNA and histone methylation have a close relationship with the development and progression of tumors. Epigenetic regulation is critical in maintaining the stability and integrity of the expression profiles of different cell types by modifying DNA methylation and histone methylation. However, the abnormal changes of methylation often result in the development and progression of tumors. This review summarized the theory of tumor genomic and histone methylation, detection methods of methylation and their applications, and the clinical application of methylation as biological markers and drug targets.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Histonas
/
Metilación de ADN
/
Genética
/
Metabolismo
/
Metilación
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2009
Tipo del documento:
Artículo
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