Survival and Prognosis Analysis of 57 Patients with Multiple Myeloma / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship of clinical related indicator levels and clinical staging with the prognosis of MM patients so as to more accurately evaluate the disease status and guide the clinical treatment.</p><p><b>METHOD</b>The clinical indicators including age, WBC and Plt counts, FISH result, ISS staging, Kappa and Lammada light chain levels and so on in 57 cases of MM were analyzed retrospectively; the unvariate and multivatiate analyses of factors influencing the prognosis of MM patients were performed by Kaplan-Meier and Cox regression model; the factors influencing the prognosis of patients were evaluated.</p><p><b>RESULTS</b>Median age of 57 patients including 25 male and 32 female, was 63(29-81) years old, mean OS time was 37.3 months, mean PFS time was 36.3 months, 3-year OS and PFS were 73.6% and 56.1% respectively. The unvaviate analysis showed that age, WBC count, Plt count, FISH result, ISS staging, Kappa and lammda light chain levels, and remission were factors influencing the prognosis; the multivatiate analysis showed that the Kappa light chain level ≥19.4 mg/L and Plt count <100×10/L were independant risk factors influencing the prognosis of MM patients.</p><p><b>CONCLUSION</b>The prognosis of MM patients with high Kappa light chian level and low Plt count is very poor, therefore the therapeutic regimens should be selected differentially for this kind of newly diagnosed MM patients so as to enhance the survival time of patients.</p>