Effect of B Cell Differentiation Markers on the Prognosis of Primary Central Nervous System Lymphoma / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the value of B-cell differentiation markers in prognosis evaluation of 119 patients with primary CNS lymphoma(PCNSL).</p><p><b>METHODS</b>The expressions of BCL-2, BCL-6, CD10 and MUM1/IRF4 protein were determined by immunohistochemistry, and their relationship with the prognosis of primary central nervous system lymphoma was analyzed.</p><p><b>RESULTS</b>Univariate analysis showed that BCL-6 positive means shorter PFS (P=0.047) and OS (P=0.035). Multivariate analysis showed that BCL-6 positive expression was related with shorter PFS (hazard ratio1.95, 95% CI 1.22- 3.12, P=0.005), but did not relate with OS (hazard ratio 1.85, 95% CI 0.71- 4.80, P=0.21). Classification based on Hans algorithm and expression status of the single B-cell markers BCL-2, CD10 and MUM1/IRF4 did not correlate with prognosis.</p><p><b>CONCLUSION</b>BCL-6 may be an unfavorable prognostic biomarker for PCNSL.</p>