Hedgehog signaling pathway and osteoporosis / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 169-172, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-301865
ABSTRACT
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoblastos
/
Osteoporosis
/
Fisiología
/
Factores de Transcripción
/
Transducción de Señal
/
Diferenciación Celular
/
Biología Celular
/
Quimioterapia
/
Subunidad alfa 1 del Factor de Unión al Sitio Principal
/
Proteínas Hedgehog
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Orthopaedics and Traumatology
Año:
2014
Tipo del documento:
Artículo
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