Lung cancer risk associated with genetic polymorphism in myeloperoxidase (-463 G/A) in a Chinese population / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 250-253, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-301962
ABSTRACT
<p><b>OBJECTIVE</b>To examine the relationship between susceptibility to lung cancer among Chinese and genetic polymorphism at nucleotide -463 (G/A) in myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes and involved in the formation of hydroxyl radicals and activation of various smoking-related carcinogens.</p><p><b>METHODS</b>The association of this polymorphism with lung cancer in a hospital-based case-control study of 314 patients and 320 age- and sex-matched controls was tested. The MPO genotypes were determined by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP).</p><p><b>RESULTS</b>The allele frequency for MPO-463A was found to be 11.0% for controls, compared with 15.0% for patients. Multivariate analysis showed an increased risk for overall lung cancer in subjects having GG genotype (OR, 1.7; 95% CI, 1.2 - 2.5), however, the elevated risk was limited to squamous cell carcinoma (OR, 2.4; 95% CI, 1.4 - 3.9; n = 177) but not to adenocarcinoma (OR, 1.3; 95% CI, 0.8 - 2.1; n = 137). In addition, the risky effect of the GG genotype on squamous cell carcinoma of the lung was evident only in the smokers and those who smoked >/= 26 pack-years (OR, 20.5; 95% CI, 5.6 - 75.3) as compared with GA and AA genotypes (OR, 6.2; 95% CI, 1.7 - 22.5) but not in the nonsmokers or those who smoked < 26 pack-years.</p><p><b>CONCLUSION</b>Our data support the hypothesis that -463A polymorphism in the MPO gene may reduce the susceptibility to lung cancer in the Chinese.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Factores de Riesgo
/
Mutación Puntual
/
Peroxidasa
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
/
Genética
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2002
Tipo del documento:
Artículo
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