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Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
Endocrinology and Metabolism ; : 124-141, 2015.
Artículo en Inglés | WPRIM | ID: wpr-30202
ABSTRACT
Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vértebra Cervical Axis / Neuropéptidos / Dinorfinas / Neuroquinina B / Estado Nutricional / Hormona Liberadora de Gonadotropina / Fertilidad / Kisspeptinas / Hipogonadismo / Hipotálamo Límite: Adulto / Humanos Idioma: Inglés Revista: Endocrinology and Metabolism Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vértebra Cervical Axis / Neuropéptidos / Dinorfinas / Neuroquinina B / Estado Nutricional / Hormona Liberadora de Gonadotropina / Fertilidad / Kisspeptinas / Hipogonadismo / Hipotálamo Límite: Adulto / Humanos Idioma: Inglés Revista: Endocrinology and Metabolism Año: 2015 Tipo del documento: Artículo