Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 786-789, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-302079
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among ischemic stroke patients and the related subtypes in the discordant sib pairs.</p><p><b>METHODS</b>Families including ischemic stroke patients and their siblings were recruited. Four single nucleotide polymorphisms (SNPs) of LTA4H as rs2072512, rs2540489, rs2540500 and rs6538697 were selected. Generalized estimating equation (GEE) was used to adjust for in-family correlation in the analysis of discordant sib pairs. Conditional logistic regression model and family based association test (FBAT) were both used to test the associations of LTA4H gene with ischemic stroke and its subtypes.</p><p><b>RESULTS</b>In total, data from 356 discordant sib pairs from 234 ischemic stroke patient pedigrees were analyzed. Results of GEE showed that hypertension, diabetes mellitus and hyperlipoidemia were associated with ischemic stroke. According to the association test results, rs2540489 G allele was found to be associated with ischemic stroke, both in the additive model (OR = 0.62, 95% CI 0.41-0.94) and in the recessive model (OR = 0.48, 95% CI 0.23-1.02). For two main ischemic stroke subtypes, rs2540489 G allele was found to be associated with large-artery atherosclerosis stroke in the additive model (OR = 0.48, 95% CI 0.24-0.95) and in the recessive model (OR = 0.25, 95% CI 0.07-0.93). After adjusting age, sex and other factors, the associations mentioned above, still existed.</p><p><b>CONCLUSION</b>rs2540489 polymorphism in LTA4H gene seemed to be associated with large-artery atherosclerosis stroke.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linaje
/
Modelos Logísticos
/
Isquemia Encefálica
/
Accidente Cerebrovascular
/
Polimorfismo de Nucleótido Simple
/
Hermanos
/
Diabetes Mellitus
/
Alelos
/
Epóxido Hidrolasas
/
Aterosclerosis
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2015
Tipo del documento:
Artículo
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