Progress of study on the roles of matrix metalloproteinases in the pathogenesis of hematologic malignancies -- review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 229-233, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-302159
ABSTRACT
Matrix metalloproteinases (MMPs) have the ability to degrade extracellular matrix components. They abnormally express in a variety of solid tumors and hematologic malignancies, and play an important role in tumor invasion and metastasis through extracellular matrix degradation, which closely relates with the progression and prognosis of the malignant disease. This article reviews progress of study on the mechanism of MMP underlying the pathogenesis of hematologic malignancies, including structure of MMP, regulation mechanism of MMP and its relation with proliferation and differentiation of hematopoietic stem cells (HSC), angiogenesis and tumor immunology and so on.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias Hematológicas
/
Metaloproteinasas de la Matriz
Tipo de estudio:
Estudio de etiología
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS