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Correlation between gene polymorphism of endothelial protein C receptor and cerebral infarction in Chinese Han population of Hubei province / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 203-205, 2009.
Artículo en Chino | WPRIM | ID: wpr-302166
ABSTRACT
In order to explore the distribution frequency of endothelial protein C receptor (EPCR) gene A6936G variant and to study the correlation between this mutation and cerebral infarction in Chinese Han population of Hubei province district. The genotype and allele frequencies of EPCR A6936G were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 380 cerebral infarction patients and 380 healthy Chinese Han persons. The results indicated that the frequencies of A/A, A/G and G/G genotypes in cerebral infarction group were 77.1%, 22.1% and 0.8% respectively. While the frequencies of A/A and A/G genotypes in control group were 88.2% and 11.8%, and without G/G genotype. It is concluded that A6936G polymorphism of EPCR can be detected in Chinese Han population of Hubei province district, which may be correlated with the increasing risk of thrombosis in cerebral infarction patients.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Antígenos CD / Estudios de Casos y Controles / Infarto Cerebral / Receptores de Superficie Celular / Pueblo Asiatico / Receptor de Proteína C Endotelial / Frecuencia de los Genes / Genética / Genotipo Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Antígenos CD / Estudios de Casos y Controles / Infarto Cerebral / Receptores de Superficie Celular / Pueblo Asiatico / Receptor de Proteína C Endotelial / Frecuencia de los Genes / Genética / Genotipo Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2009 Tipo del documento: Artículo