Experimental study of Eudragit mixture as a new nonadhesive liquid embolic material / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To assess the embolic effects and biocompatibility of Eudragit mixture, a new liquid embolic agent.</p><p><b>METHODS</b>In vitro, the viscosity and precipitation time of Eudragit mixtures at several concentrations were measured to study the best proportion of components of the mixture. In vivo, a branch of the right external carotid artery was embolized with Eudragit mixture in 12 rabbits, and with n-butyl cyanoacrylate in another 12 rabbits for a comparative study of the general, angiographic and histopathologic changes between the two groups.</p><p><b>RESULTS</b>Eudragit mixture containing 7.5 g Eudragit, 50 ml absolute ethanol and 50 ml iopromide was shown in vitro to have good properties including rapid precipitation and soft elastic sponge formation upon contact with blood; in vivo, to be nontoxic, nonadherent to the microcatheter and able to embolize the vascular lumen completely without later recanalisation.</p><p><b>CONCLUSION</b>Eudragit mixture is an effective, nontoxic, safe and promising liquid embolic agent.</p>