Suppression of gamma-aminobutyric acid transporter current by activation of ionotropic glutamate receptors on retinal horizontal cells / 生理学报
Acta Physiologica Sinica
;
(6): 299-304, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-302448
ABSTRACT
In the present study, the modulatory effect of AMPA receptors on gamma-aminobutyric acid (GABA) transporter current was investigated on enzymatically isolated horizontal cells of carp retina. The GABA transporter current elicited by 1 mmol/L GABA was decreased immediately after pre-application of AMPA (30 mumol/L or 3 mmol/L) for 50 s. Application of 10 mmol/L BAPTA in intracellular solution inhibited the suppression effect of AMPA on GABA transporter current. The suppression effect induced by co-application of 3 mmol/L AMPA and 3 mmol/L NMDA was similar to that of 3 mmol/L AMPA or 3 mmol/L NMDA alone. These results suggest that the activation of AMPA receptors inhibits GABA transporter-mediated current by affecting intracellular Ca(2+) processes in the retinal horizontal cells, which is identical with the modulatory effect of NMDA receptors on GABA transporters.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Carpas
/
Ácido Egtácico
/
Células Horizontales de la Retina
/
Proteínas Transportadoras de GABA en la Membrana Plasmática
/
Receptores Ionotrópicos de Glutamato
/
Ácido gamma-Aminobutírico
/
Metabolismo
Límite:
Animales
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2009
Tipo del documento:
Artículo
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