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Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866 / 药学学报
Acta Pharmaceutica Sinica ; (12): 691-694, 2004.
Artículo en Chino | WPRIM | ID: wpr-302735
ABSTRACT
<p><b>AIM</b>To clarify mechanisms that the antiarrhythmic effects of matrine and berbamine are weaker than those of amiodarone and RP58866.</p><p><b>METHODS</b>Experimental arrhythmic models were induced by aconitine, coronary artery ligation and electric stimulation in rats and rabbits. Whole-cell patch-clamp techniques were used to record IK1, IKr, IKs and Ito.</p><p><b>RESULTS</b>Matrine and berbamine significantly increased the dose of aconitine for induction of ventricular premature and ventricular tachycardia in rats, decreased the number of arrhythmias induced by coronary artery ligation in rats and increased ventricular fibrillation threshold (VFT) induced by electric stimulation in rabbits, but the anti-arrhythmic potency of matrine and berbamine was lower than that of amiodarone and RP58866. The inhibitory actions of matrine and berbamine on IK1, IKr, IKs, Ito were lower than those of amiodarone and RP58866. The IC50 of matrine for IK1, IKr, IKs, Ito were (46 +/- 3), (32.9 +/- 1.2), (37 +/- 8) and (7.6 +/- 0.5) mol x L(-1), respectively. The IC50 of amiodarone for IK1, IKr, IKs, Ito were (21 +/- 5) , (3.7 +/- 0.7), (5.9 +/- 0.9) and (5.9 +/- 0.6) mol x L(-1), respectively.</p><p><b>CONCLUSION</b>The inhibitory actions of matrine and berbamine on IK1, IKr, IKs, Ito were lower than those of amiodarone and RP58866, which might be the reason that the antiarrhythmic effects of matrine and berbamine were weaker than those of amiodarone and RP58866.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Piperidinas / Arritmias Cardíacas / Quinolizinas / Aconitina / Canales de Potasio / Cromanos / Bencilisoquinolinas / Alcaloides / Cobayas Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Piperidinas / Arritmias Cardíacas / Quinolizinas / Aconitina / Canales de Potasio / Cromanos / Bencilisoquinolinas / Alcaloides / Cobayas Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2004 Tipo del documento: Artículo