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Biodistribution and hepatocytes targeting of cationic liposomes surface-modified with sterylglucoside and golyethylene glycol / 药学学报
Acta Pharmaceutica Sinica ; (12): 551-555, 2004.
Artículo en Chino | WPRIM | ID: wpr-302764
ABSTRACT
<p><b>AIM</b>To investigate the biodistribution and the hepatocytes targeting of cationic liposome containing 3beta[N-( N',N'-dimethylaminoethane) carbamoyl] cholesterol (DC-Chol) and surface-modified liposomes with sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE).</p><p><b>METHODS</b>Cationic liposomes (CL) composed of DC-Chol and dipalmitoylphosphatidylcholine (DPPC), SG/PEG modified cationic liposome (SG/PEG-CL), both contained trace 3H-cholesterol (3H-Chol) as radiolabel, were prepared. The liposomes encapsulating 125I-labled antisense oligodeoxynucleotide (125I-asODN) (SG/PEG-CL-asODN) were also prepared. The biodistribution of CL, SG/PEG-CL, SG/PEG-C2-asODN as well as 125I-asODN solution, were studied. The radioactivities in hepatocytes and non-hepatocytes after administration of CL and SG/PEG-CL were determined by infuseing method.</p><p><b>RESULTS</b>CL and SG/PEG CL significantly aggregated in liver. The distribution of SG/PEG CL was significantly higher in hepatocytes (P < 0.01) and lower in non-hepatocytes (P < 0.01) than that of CL. The concentrations of SG/PEG-CL-asODN in liver and spleen were significantly higher than that of asODN solution (P < 0.01).</p><p><b>CONCLUSION</b>Cationic liposome modified with SG/PEG changed the distribution of asODN. Cationic liposome can target hepatocytes more effective after being modified with SG.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfatidiletanolaminas / Polietilenglicoles / 1,2-Dipalmitoilfosfatidilcolina / Portadores de Fármacos / Farmacocinética / Distribución Tisular / Colestenos / Colesterol / Sistemas de Liberación de Medicamentos / Área Bajo la Curva Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfatidiletanolaminas / Polietilenglicoles / 1,2-Dipalmitoilfosfatidilcolina / Portadores de Fármacos / Farmacocinética / Distribución Tisular / Colestenos / Colesterol / Sistemas de Liberación de Medicamentos / Área Bajo la Curva Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2004 Tipo del documento: Artículo