Biotransformation of dehydroepiandrosterone by hairy root cultures of Anisodus tanguticus / 药学学报
Acta Pharmaceutica Sinica
;
(12): 445-448, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-302789
ABSTRACT
<p><b>AIM</b>To modify the structure of dehydroepiandrosterone (DHEA).</p><p><b>METHODS</b>Using hairy root cultures of Anisodus tanguticus to perform biotransformation of DHEA, using chromatographic and spectral techniques to isolate and identify the products.</p><p><b>RESULTS</b>(1) The MS medium without plant hormone was suitable for the growth of the hairy root. (2) DHEA was converted into five products androst-4-ene-3, 17-dione (I); 6alpha-hydroxyandrost-4-ene-3, 17-dione (II); 6alpha, 17beta-dihydroxyandrost-4-ene-3-one (III); androst-4-ene-3, 6, 17-trione (IV) and 17beta-hydroxyandrost-4-ene-3-one (V).</p><p><b>CONCLUSION</b>It is the first time to use hairy root cultures of Anisodus tanguticus for the biotransformation of DHEA and five DHEA-related compounds were obtained.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas Medicinales
/
Biotransformación
/
Estructura Molecular
/
Química
/
Deshidroepiandrosterona
/
Raíces de Plantas
/
Solanaceae
/
Medios de Cultivo
/
Técnicas de Cultivo de Tejidos
/
Androstenodiona
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2004
Tipo del documento:
Artículo
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