Correlation of KRAS gene mutations and clinicopathologic parameters in colorectal carcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 603-606, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-303510
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between KRAS gene mutations and clinicopathological parameters in patients with colorectal carcinoma (CRC).</p><p><b>METHODS</b>PCR-based direct sequencing was used to detect the mutations of KRAS gene and to correlate between clinicopathological characteristics and the presence of various KRAS mutations in 244 cases of CRC.</p><p><b>RESULTS</b>KRAS mutations were identified in 92 cases (37.7%) of CRC. Five types of mutation were detected at codon 12, including G12D (40 cases, 16.4%), G12V (16 cases, 6.6%), G12A (7 cases, 2.9%), G12S (5 cases, 2.0%) and G12C (4 cases, 1.6%). Two types of mutation were detected at codon 13, including G13D (17 cases, 7.0%) and G13C (2 cases, 0.8%). One type of mutation was detected in codon 61, i.e. Q61K (1 case, 0.4%). KRAS mutation rate was higher in females (45.6%, 36/79) than in males (32.1%, 53/165; P < 0.05), but not related to another clinicopathological characteristics.</p><p><b>CONCLUSIONS</b>Female CRC patients have a higher KRAS mutation rate than the male patients. KRAS mutation has no significant correlation with patient's age, tumor site, tumor gross appearance, degree of differentiation, depth of invasion, TNM stages, lymphatic invasion, abdominal or distant metastases and prognosis in this study.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Cirugía General
/
Codón
/
Neoplasias Colorrectales
/
Factores Sexuales
/
Reacción en Cadena de la Polimerasa
/
Tasa de Supervivencia
/
Proteínas Proto-Oncogénicas p21(ras)
/
Proteínas Proto-Oncogénicas
/
Análisis de Secuencia de ADN
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2012
Tipo del documento:
Artículo
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