Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats
Asian Pacific Journal of Tropical Biomedicine
;
(12): 910-915, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-303584
ABSTRACT
<p><b>OBJECTIVE</b>To assess the effect of quercetin (flavonoid) against lindane induced alterations in lipid profile of wistar rats.</p><p><b>METHODS</b>Rats were administered orally with lindane (100 mg/kg body weight) and quercetin (10 mg/kg body weight) for 30 days. After the end of treatment period lipid profile was estimated in serum and tissue.</p><p><b>RESULTS</b>Elevated levels of serum cholesterol, triglycerides, low density lipoprotein (LDL), very Low Density Lipoprotein (VLDL) and tissue triglycerides, cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.</p><p><b>CONCLUSIONS</b>Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids. The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Quercetina
/
Hexaclorociclohexano
/
Sangre
/
Química
/
Ratas Wistar
/
Estrés Oxidativo
/
Metabolismo de los Lípidos
/
Lípidos
/
Hígado
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2012
Tipo del documento:
Artículo
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